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Chapter 8: Pregnenolone – Your Brain Power

165 High doses of Pregnenolone prescribed as miracle drug for Rheumatoid Arthritis in 1950s: J Lancet1950 Jul;70(7):264-5 Cohen A et al.
165 Pregnenolone historically regarded as “mother of all hormones”: J Steroid Biochem Mol Bioc. 1991;40(1-3):71-81 Akwa Y et al.
166 Pregnenolone gives more alert feeling by suppressing GABA: Acta Physiol (OXF). 2006 Nov;188(3-4):153-62 Wang MD et al.
166 Pregnenolone protects from negative effects of increased glutamate by increasing dopamine: Pharmacol Biochem Behav. 2004 Aug;78(4):781-6 Maciejak P et al.
166 Pregnenolone protects brain cells from Amyloid Beta Protein that is associated with alzheimer: Neurochem Res. 2001 Jan;26(1):15-21 Gursog et al.
166 Less frequently the beta form of pregnenolone increases GABA: J Clin Endocrinol Metab. 2006 Aug;91(8):3092-9 Havlikova H et al.
166 Pregnenolone increases capacity for cognitive function: Pharmacol Biochem Behav. 2004 Aug;78(4):781-6 Maciejak P et al.; Neuroscience. 2005;133(1):147-57 Shirayama Y et al.
166 Pregnenolone improves new brain cell generation: Prog Neurobiol. 2003 Sep;71(1):43-8 Mayo W et al.
166 Pregnenolone supports over-all memory by increasing acetylcholine: Brain Res. 2000 Jan 3;852(1):173-9 Darnaudery M et al.; Prog Neurobiol. 2003 Sep;71(1):43-8 Mayo W et al.
166 Pregnenolone specifically increases spatial memory: J Neuroscience. 2006 Oct 25;26(43):11034-40 Yau JL et al.
166 Pregnenolone increases memory in the aged: Brain Res Brain Res Rev. 2001 Nov;37(1-3):301-12 Vallee M et al.
166 Prozac or Fluoxetine increase level of pregnenolone in brain: Pharmacol Biochem Behav. 2006 Aug;84(4):609-17 Marx CE et al.
168 Drinking alcohol increases pregnenolone in brain: Psychopharmacology. 2006 Jun;186(3):451-61 Pierucci-Lagha A et al.
168 Our body increases pregnenolone when sedative medication is taken: Psychneuroendocrinology. 2004 May;29(4):486-500 Meieran Se et al.
170 People with social-phobias have naturally low levels of pregnenolone: Psychol Med. 2002 Jul;32((5):929-33 Heydari B et al.
170 Pregnenolone is found in concentrated levels in the eye: Brain Res Brain Res Rev. 2001 Nov;37(1-3):301-12 Vallee M et al.
171 500mg daily of pregnenolone were prescribed in 1950s with no side effect: J Lancet. 1950 Jul;70(7):264-5 Cohen A et al.
171 Studies indicate presence of pregnenolone decreases cholesterol levels as a complete HRT program: Med Hypoteses. 2002 Dec;59(6):751-6 Ozugan SA et al.; Gastroenterology. 1984 Aug;87(2):284-92. Turley SD et al.
171 Pregnenolone plays important role in embryonic process: Nature. 2006 Jan;439(7075):480-3 Hsu HJ et al.

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