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Chapter 7: DHEA – The Master Hormone

144 By ages 50-60 most will lose 70% of DHEAS level enjoyed in 20s: Endo Reviews. 2003 Apr;24(2):152-182 Labrie F et al.; J Clin Endo Met. 1992;75(4):1002-4 Orentreich N et al.; J Clin Endocrinol Metab. 1984;59(3):551-5. Orentreich N et al.
144 DHEA levels peak between ages 20-30/plummet between ages 50-60: Endo Reviews. 2003 Apr;24(2): 152-182 Labrie F et al.; J Clin Endo Met. 1992;75(4): 1002-4 Orentreich N. et al.
144 DHEA levels decline less after age 60: J Clin Endo & Metab. 1997 ;82: 2396-2402 Lebrie F et al.
144 Measurable decline in DHEA production after hysterectomy: Fertil Steril. 2006 Oct;86(4): 981-9 Hassa H et al.
146 Promising reports of DHEA: Fertil Steril. 2003 Dec;80(6): 1495-501 Genazzani AD et al.; J Clin Endocrinol Metab. 1999;84(9)3260-7 Solerte SB et al.; Endocr Rev. 2003 Apr;24(2): 152-82 Labrie F et al.; Cell Mol Immunol. 2006 Feb;3(1): 41-5 Wang YD et al.; J Clinic Endo and Metab. 2002 May;87(5): 2046-52 Gudmundur J et al.
146 Negative DHEA reports: N Engl J Med. 2006 Oct 19;355(16): 1647-59 Nair KS et al.; Semin Reprod Med. 2006 Apr;24(2): 97-105 Saltzman E et al.; Treat Endocrinol. 2005;4(2): 95-114 Cameron DR et al.; Trends Endocrinol Metab. 2002 Sep;13(7): 288-94 Allolio B et al.
146 DHEAS—ready to use when needed: Endocr Rev. 2003 Apr;24(2): 152-82 Labrie F et al.
147 Androgens play important role in women’s health: Gynecol Endocrinol. 2006 Mar;22(3): 118-30 Labrie F.
147 Supplementing DHEA decreases breast cancer: Endo Reviews. 2003 Apr;24(2): 152-182 Labrie F et al.; World J Surgery. 2007 Apr 4; Published Online Hardin C et al.
147 DHEA suppressed growth of human breast cancer cells in mice: Carcinogenesis 2003;105(3):321-325. Ciolino H et al.; Cancer J. 2006 Mar-Apr;12(2):160-5. Gayosso V et at.; Breast Cancer Res. 2005;7(6):R1132-40. Shilkaitis A et al.
147 DHEA inhibits progression of breast cancer: Cáncer J. 2006 Mar-Apr;12(2): 160-5 Gayosso V et al.; Breast Cancer Res. 2005;7(6) R1132-40 Shilkaitis A et al.
147 Aromatase inhibitors (regular breast cancer treatment) in the absence of androgens are not as efficient as could be: Endocrin-Related Cancer. 2006 Aug 1;13: 335-355 Labrie F.; Cancer Res. 2006 Aug 1;66(15): 7775-7782 Macedo LF et al.
147 DHEA suppresses production of 4 Hydroxy esterone (that may increase breast cancer): CG. Mol Cell Biochem. 1999;198: 89-100. Ikegwuonu FI et al.; Carcinogenesis 2003;105(3):321-325 Ciolino H et al.
148 Multiple studies show general anti-cancer effect of DHEA: Cancer Lett. 1997 Jun 3;116(1): 61-69 Wang TT et al.; Carcinogenesis 2003;105(3):321-325. Ciolino H et al.
148 Animal studies indicate anti-cancerous effect of DHEA on pancreatic cancer: Surgery. 1997;121(4): 392-7 Melvin WS et al.
148 Animal studies indicate anti-cancerous effect of DHEA on colon cancer: Carcinogenesis. 1984;5(1): 57-62 Nyce JW et al.; Cancer Res. 1992;52:1372-76. Schulz S et al.
148 Animal studies indicate anti-cancerous effect of DHEA on prostate cancer: Cancer Res. 1999 Jul 1;59(13): 3084-9 Rao KV et al.
148 DHEA benefits the cardiovascular system: J Cardiovasc Pharmacol. 2005 Sep;46(3): 325-32 Hutchison SJ et al.; Endocrinol Pol. 2005 Nov-Dec;56(6): 904-10 Rabijewski M et al.; Circulation. 1993;87: 261-9 Eich DM et al.
148 Low DHEA associated with increase atherosclerosis: Euro J Endocrinol. 2007 Jun;156(6):687-93
148 DHEA inhibits platelet aggregation: Ann NY Acad Sci. 1995;774: 281-90 Jesse RL et al.
148 DHEA reverse aging process of left heart ventricle: Am J Physiol Regul Integr Comp Physiol. 2006 Jan;290(1): R251-6 Alwardt CM et al.
148 DHEA protects the cardio vascular system: J Nut Cancer Inst. 1998 may 20;90(10):772-80. Couillard S et al.
148 DHEA is high in Polycistic Ovarian Syndrome patients as cardio protective reponse by their bodies: Eur J Endocrinol. 2006 Jun;154(6): 883-90 Dagre A et al.
149 DHEA improves overall condition of diabetes: Ann NY Acad Sci. 1995;774: 291-3 Bates GW et al.
149 DHEA improves insulin sensitivity: Euro J Endo. 2001 Oct;145(4): 457-61 Lasco A et al.
149 DHEA increases pancreatic cells: FEBS Lett. 2006 Jan 9;580(1): 285-90 Medina MC et al.
149 EA decreases insulin resistance in people with coronary disease: Endokrynol Pol. 2005 Nov-Dec;56(6): 904-10 Rabijewski M et al.
149 DHEA protects diabetic patients from oxidative stress: Diabetes Care. 2007 Aug 17; Brignardello E et al.
149 DHEA increases adiponectin: Endocrinology Reviews. 2005;26(3): 439-451 Kadowaki T et al.
149 Supplementing DHEA up-regulates adiponectin levels: Eur J Endocrinol. 2006 Oct;155(4): 593-600 Hernandez-Morante JJ et al.
149 DHEA increases NK activity: J Clin Endocrinol Metab. 1999;84(9)3260-7 Solerte SB et al.
149 DHEA slows onset of autoimmune disease: Autoimmunity. 1997;26(3): 161-71 Norton SD et al.
150 DHEA improves wound healing: J Invest Dermatol. 2005 Nov;125(5): 1053-62 Mills SJ et al.
150 DHEA Enhances body’s response to viral disease: J Gen Virol. 2005 Sep;86(9): 2513-23 Chang CC et al.
150 DHEA enhances body’s response to parasite and bacteria: Crit Care Med. 2001;29(2): 380-4 Berbeck R et al.
150 DHEA reduces body’s inflammation response: J Interferon Cytokine Res. 2006 Jan;26(1): 34-9 Powell JM et al.
150 DHEA decreases pro-inflammatory cytokines: Atherosclerosis. 2006 Mar 28; Gutierrez G et al.; J Clin Endo Metab. 2004 Jul;89(7): 3449-54 Iwasaki Y et al.
150 DHEA decreases incidence of cold, flu, and allergies: Vaccine. 1995;13(15)L1445-8. Danenberg HD et al.; J Am Geriatr Soc. 1997 Jun;45(6):747-51. Degelau J et al.; J Microbiol Immunol Infect. 2002 Sep;35(3):199-202. Yu CK et al.; J Rheumatol. 2001 Jun:28(6):1259-65. Valtysdottir ST et al.
150 DHEA reduces colitis: Endocrinology. 1997 Aug;138(8):3387-94 Luo S et al.
150 DHEA reduces endometriosis: Atherosclerosis. 2006 Mar 28; Gutierrez G et al.
150 DHEA reduces lupus: Curr Opin Invstig Drugs. 2001 Aug;2(8): 1045-53 Dequet CR et al.; Autoimmunity. 2005 Nov;38(7): 531-40 Nordmark G et al.
150 DHEA reduces psoriasis: Clin Exp Rheumatol. 1995 May-Jun;13(3): 345-8 De La Torre B et al.
150 DHEA reduces rheumatoid arthritis: Arthritis Rheum. 2005 Jun;52(6): 1721-9 Weidler C et al.; J Rheumatol. 2000;59 Suppl 2: II/108-18 Straub RH et al.; J Rheumatol. 2002 Aug;29(8): 1803-5 Josipovic B et al.
150 DHEA reduces osteoarthritis and joint pain: Rheumatol Int. 2006 Oct 11; Wu LD et al.
150 DHEA functions as general anti-oxidant: Endocrinology. 1997 Aug;138(8): 3387-94 Luo S et al.; Cancer Res. 2001 Oct 15;61(21)7449-55. Green J et al.; Brain Res Mol Brain Res. 1999;66(1-2):35-41. Bastianetto S et al.
150 DHEA decreases depression and improve felling of well-being: J Clin Endocrinol Metab. 2006 Oct ;91(10): 3773-9 Brooke AM et al.; Am J Psychiatry. 2006 Jan;163(1): 59-66 Rabkin JG et al.; J Clinic Endo and Metab. 2002 May;87(5): 2046-52 Gudmundur J et al.; Amer J Psychiatry. 1999 Apr;156(4): 646-9 Woldowitz OM et al.; Autoimmunity. 2005 Nov;38(7): 531-40 Nordmark G et al.
150 DHEA treatment may resolve depression in children: Eur Neuropsychopharmacol. 2007 Aug 20; Malkesman O et al.
150 DHEA shown to reduce anxiety: Pharmacol Biochem Behav. 1994 Mar;47(3): 437-41 Melchior CL et al.
151 DHEA decreases cortisol: Acta Psychiatr Scand. 2006 Sep;114(3): 187-93 Yehuda R et al.; J Clin Endocrinol Metab. 1996 Nov;81(11): 3951-60 Guazzo EP et al.
151 DHEA increases estrogen: Endocr Rev. 2003 Apr;24(2): 152-82 Labrie F et al.
151 DHEA increases progesterone and allopregnenolone: Maturitas. 2003 Jul 25;45(3): 231-5 Nadjafi-Triebsch C et al.
151 DHEA decrease pain: FASEB J. 2007 Aug 24; Kibaly C et al
151 DHEA protects the hippocampus from injury and free-radicals: J Neurochem. 2002 Nov;83(3): 713-26 Steckelbroeck S et al.; Neuropharmacology. 2006 Oct;51(5): 958-66 Li Z et al.; Brain Res Mol Brain Res. 1999;66(1-2): 35-41 Bastianetto S et al.
151 DHEA an effective treatment in vascular and neuronal-related disease: Amer J Physiol Endocrinology and Metabolism. 2002 Nov;283(5): E1067-75 Yorek MA et al.
151 DHEA improves muscle mass and strength following resistance exercises: Am J Physiol Endocrinol Metab. 2006 Nov;291(5): E1003-8 Villareal DT et al.
151 DHEA improves bone mass: Cell Mol Immunol. 2006 Feb;3(1):41-5. Wang YD et al.; Clin Endocrinol (OXF). 2000 Nov;53(5): 561-8 Villareal DT et al.
152 DHEA improves bone density in spine: J Clin Endocrinol Metab. 2006 Aug;91(8): 2986-93 Jankowski CM et al.
152 DHEA decreases bone loss: Cell Mol Immunol. 2006 Feb;3(1): 41-5 Wang YD et al.
152 DHEA necessary for high-altitude acclimation: High Alt Med Biol. 2006 Fall;7(3): 228-36 Lee WC et al.
152 DHEA affects sexual arousal and response: Fertil & Steril. 2002 Apr;77(4): S19-S25 Spark RF.
152 DHEA megadose in double-blind studies showed increased sex drive and better orgasmic response: J Womens Health Gend Based Med. 2002 Mar;11(2): 155-62 Hackbert L et al.
153 DHEA increases HGH: Clin Endocrinol. (OXF). 2006 Nov;65(5): 673-80 Brooke AM et al.; Fertil and Steril. 2001 Aug;76(2)241-248 Genazzani AL et al.
153 DHEA increases allopregnenolone and endorphins: Fertil Steril. 2003 Dec;80(6): 1495-501 Genazzani AD et al.
153 DHEA converts into estrogen: Endocr Rev. 2003 Apr;24(2): 152-82 Labrie F et al.
153 DHEA increases progesterone levels: Maturitas. 2003 Jul 25;45(3): 231-5 Nadjafi-Triebsch C et al.
153 DHEA reduces cortisol: Encephale. 2002 Mar-Apr;28(2): 139-46 Boudarene M et al.; Acta Psychiatr Scand. 2006 Sep;114(3): 187-93 Yehuda R et al.; J Clin Endocrinol Metab. 1996 Nov;81(11): 3951-60 Guazzo EP et al.
153 DHEA decreases high levels of cortisol: Encephale. 2002 Mar-Apr;28(2): 139-46 Boudarene M et al.
154 Women with adrenal deficiency and low cortisol tolerate higher levels of DHEA: Treat Endocrinol. 2005;4(2): 95-114 Cameron DR et al.
154 DHEA can correct Graves’ Disease and Hashimoto’s Thyroiditis: Eur J Endocrinol. 2005 May;152(5): 703-12 Solerte SB et al.
154 DHEA decreases hot flashes: Endo Reviews. 2003 Apr;24(2): 152-182 Labrie F et al.
154 DHEA reduces middle ear infections: J Pharmacol Sci. 2005 Oct;99(2): 191-4 Tabuchi K et al.
154 DHEA improves fertility treatment in previously unresponsive women: Human Reprod. 2006 Nov;21(11)2845-9 Barad D et al.
155 DHEA levels rise with the implementation of Natural Superwoman eating: Exp Gerontol. 2003 Jan-Feb;38(1-2): 35-46 Mattison JA et al.
155 Study indicating that people with lower levels of DHEA were more likely to die during course of three year study: Ann Epidemiol. 2006 Jul;16(7): 510-5 Glei DA et al.
157 Why studies that include women with Policystic Ovarian Syndrome are misleading?: Obstet Gnecol Surv. 2006 Nov;61(11): 723-32 Himelein MJ et al.; ARQ Bras Endocrinol Metab. 2005 Oct;49(5): 805-10 Spritzer PM et al.
157 In women with Polycystic Ovarian Syndrome high level of DHEA are protective: Eur J Endocrinol. 2006 Jun;154(6): 883-90 Dagre A et al.
157 Study reporting 17 women given 50 mg. DHEA with an absence of side effects, it makes no sense that they had no side effects: J Clin Endocrinol Metab. 1994 Jun;78(6): 1360-7 Morales AJ et al.
158 Majority of studies on liver cancer treatment with DHEA show reduced proliferation: Int J Oncol. 2004 Oct;25(4): 1021-30 Mayer D et al.
158 Extremely high dose given for very long time to achieve negative effect: Cancer Lett. 1997 Dec 23;121(2): 125-31 Metzger C et al.
160 Sublingual DHEA administration: Climacteric. 2003 Jun;6(2): 104-11 Wren BG et al.
160 Benefits of micronized form of DHEA: Am J Obstet Gynecol. 1996 Feb;174(2): 649-53 Casson PR et al.
162 Opposite-than-expected response is usually due to low Norepinephrine levels: Neuroscie Lett. 1996 Feb 9;204(3):181-4 Liu PS et al.
163 Ginseng enhances DHEA effectiveness: CMAJ. 2006 Apr 11;174(8): 1134 Howard JM.

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